%0 Journal Article
%T Coexisting FGFR3 p.K650T mutation in two FGFR3-TACC3 fusion glioma cases
%A Jason T. Huse
%A Leomar Y. Ballester
%A Norman E. Leeds
%A Soheil Zorofchian Moghadamtousi
%J Archive of "Acta Neuropathologica Communications".
%D 2019
%R 10.1186/s40478-019-0721-7
%X Imaging and histologic features of Patient #1. Preoperative MR imaging showing T2 FLAIR hyperintensity in the right temporal lobe (a) with minimal contrast enhancement in the T1 sequence with contrast (b). H&E-stained tumor tissue sections showing hypercellular brain parenchyma with microcalcifications. The brain parenchyma is infiltrated by monomorphic round glial cells with perinuclear clearing, resembling oligodendrocytes (c). Spindle cells in a perivascular distribution are noted (d). GFAP is positive in tumor cells (e), and Ki67 immunostaining shows a low proliferation index (f). Surveillance MR imaging showing T2 FLAIR hyperintensity around the surgical cavity (g) and new contrast enhancement along the resection cavity wall (h). H&E-stained tumor tissue sections show hypercellular brain parenchyma with oligo-like cells and perivascular pseudorosettes (i), and an endocrinoid (¡°chickenwire¡±) capillary network (j). The tumor cells are strongly positive for CD34 (k) and the Ki67 index is elevated (l) in comparison to the tumor resected in the first surgery (d
%K FGFR3
%K TERT
%K Glioblastoma
%K Glioma
%K FGFR3-TACC3 fusion
%K NF1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487516/