%0 Journal Article
%T DNA methylation GrimAge strongly predicts lifespan and healthspan
%A Abraham Aviv
%A Ake T. Lu
%A Alex P. Reiner
%A Andrea A. Baccarelli
%A Austin Quach
%A Eric A. Whitsel
%A James D. Stewart
%A James G. Wilson
%A Kenneth Raj
%A Lifang Hou
%A Luigi Ferrucci
%A Steve Horvath
%A Themistocles L. Assimes
%A Yun Li
%J Archive of "Aging (Albany NY)".
%D 2019
%R 10.18632/aging.101684
%X It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators of plasma proteins including those of plasminogen activator inhibitor 1 (PAI-1) and growth differentiation factor 15. The resulting predictor of lifespan, DNAm GrimAge (in units of years), is a composite biomarker based on the seven DNAm surrogates and a DNAm-based estimator of smoking pack-years. Adjusting DNAm GrimAge for chronological age generated novel measure of epigenetic age acceleration, AgeAccelGrim
%K DNA methylation GrimAge strongly predicts lifespan and healthspan
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366976/