%0 Journal Article
%T Cav1.2 regulates osteogenesis of bone marrow©\derived mesenchymal stem cells via canonical Wnt pathway in age©\related osteoporosis
%A Anqi Liu
%A Bei Li
%A Dongdong Fei
%A Hui Zhang
%A Jinjin Wang
%A Junjie Wu
%A Qintao Wang
%A Xiaoning He
%A Yang Zhang
%J Archive of "Aging Cell".
%D 2019
%R 10.1111/acel.12967
%X Age©\related bone mass loss is one of the most prevalent diseases that afflict the elderly population. The decline in the osteogenic differentiation capacity of bone marrow©\derived mesenchymal stem cells (BMMSCs) is regarded as one of the central mediators. Voltage©\gated Ca2+ channels (VGCCs) play an important role in the regulation of various cell biological functions, and disruption of VGCCs is associated with several age©\related cellular characteristics and systemic symptoms. However, whether and how VGCCs cause the decreased osteogenic differentiation abilities of BMMSCs have not been fully elucidated
%K age©\related bone mass loss
%K bone marrow©\derived mesenchymal stem cells
%K osteogenic differentiation
%K voltage©\gated Ca2+ channels
%K Wnt/¦Â©\catenin signaling
%K Zmpste24
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612635/