%0 Journal Article
%T Anti-TPO IgE Autoantibody in Chronic Urticaria: Is It Clinically Relevant?
%A Bastsetseg Ulambayar
%A Hae-Sim Park
%J Archive of "Allergy, Asthma & Immunology Research".
%D 2019
%R 10.4168/aair.2019.11.1.1
%X Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by recurrent itchy wheals, angioedema or both which lasts more than 6 weeks with prevalence of 0.5% to 1%.1 Although immunologic mechanisms of CSU have not yet been fully understood, it has been suggested that autoimmunity is one of the major cause of activation of mast cells in CSU, where 2 types of autoimmune reactions are involved.2,3 Type I autoimmune reaction (autoallergy) is an IgE response reacting to self-antigens that induce mast cells/basophils to release histamine and vasoactive mediators. Type II autoimmunity is explained by the presence of IgG autoantibodies against IgE or high affinity Fc epsilon receptor I (Fc¦ÅRI), which leads to the degranulation of mast cells/basophils.3 There have been several studies to show a positive association between autoimmune thyroid disease and CSU, and a higher prevalence of serum IgG autoantibody to thyroid peroxidase (TPO) and thyroglobulin (TG) were noted in adult and pediatric patients with CSU.3,4,5,6,7 IgG autoantibody to Fc¦ÅRI was detected in CSU patients which was correlated with autologous serum skin test (ASST) results.8 In addition, recent studies demonstrated higher prevalence of IgE autoantibodies to thyroid antigens including TPO in sera of CSU, which could induce activation of basophils, suggesting involvement of IgE-mediated autoimmune mechanism in the pathogenesis of CSU.9,1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267193/