%0 Journal Article
%T A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma
%A Jin Hai Zheng
%A Joon Haeng Rhee
%A Tra-My Nu Duong
%A Wenzhi Tan
%A Young-Il Koh
%J Archive of "Allergy, Asthma & Immunology Research".
%D 2019
%R 10.4168/aair.2019.11.2.254
%X The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated that Vibrio vulnificus flagellin B (FlaB) plus allergen as a co-treatment mixture improved lung function and inhibited eosinophilic airway inflammation through the Toll-like receptor 5 signaling pathway in an ovalbumin (OVA)- or HDM-induced mouse asthma model. In the present study, we fused the major mite allergen Derp2 to FlaB and compared the therapeutic effects of the Derp2-FlaB fusion protein with those of a mixture of Derp2 and FlaB in a Derp2-induced mouse asthma model
%K Asthma
%K Derp2
%K FlaB flagellin
%K fusion protein
%K Toll-like receptor 5
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340794/