%0 Journal Article %T Alzheimer's disease Archimedes condition-event simulator: Development and validation %A Ali Tafazzoli %A K. Jack Ishak %A Stanmira Krotneva %J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions". %D 2018 %R 10.1016/j.trci.2018.01.001 %X Several advances have been made in Alzheimer's Disease (AD) modeling, however, there remains a need for a simulator that represents the full scope of disease progression and can be used to study new disease-modifying treatments for early-stage and even prodromal AD %K Alzheimer's disease (AD) %K Prodromal AD %K Disease-modifying treatments %K Simulation %K Cost-effectiveness analysis %K Biomarkers %K Predictive equations %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910516/