%0 Journal Article
%T The metabolic modulator PGC-1¦Á in cancer
%A Frederic Bost
%A Lisa Kaminski
%J Archive of "American Journal of Cancer Research".
%D 2019
%X The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1¦Á) is a central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer cells, thus, it is not surprising that PGC-1¦Á plays a role in cancer. Several recent articles have shown that PGC-1¦Á expression is altered in tumors and metastasis in relation to modifications in cellular metabolism. The potential uses of PGC-1¦Á as a therapeutic target and a biomarker of the advanced form of cancer will be summarized in this review
%K PGC1 alpha
%K prostate cancer
%K melanoma
%K breast cancer
%K pancreatic cancer
%K metabolism
%K mitochondria
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405967/