%0 Journal Article
%T Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice
%A FeiŠ\fei Guan
%A LianŠ\feng Zhang
%A Ning Liu
%A Shan Gao
%A Wei Chen
%A Wei Dong
%A Xu Zhang
%J Archive of "Animal Models and Experimental Medicine".
%D 2018
%R 10.1002/ame2.12007
%X 24Š\dehydrocholesterol reductase (Dhcr24) catalyzes the last step of cholesterol biosynthesis, which is required for normal development and antiŠ\apoptotic activities of tissues. We found that Dhcr24 expression decreased in the cTnTR 141W dilated cardiomyopathy (DCM) transgenic mice. Therefore, we tested whether rescued expression of Dhcr24 could prevent the development of DCM and its possible mechanism
%K apoptosis
%K Dhcr24
%K dilated cardiomyopathy
%K gene expression and regulation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354314/