%0 Journal Article %T Classification review of dental adhesive systems: from the IV generation to the universal type %A Afrah Sofan %A Eshrak Sofan %A Gaspare Palaia %A Gianluca Tenore %A Guido Migliau %A Umberto Romeo %J Archive of "Annali di Stomatologia". %D 2017 %R 10.11138/ads/2017.8.1.001 %X Adhesive dentistry has undergone great progress in the last decades. In light of minimal-invasive dentistry, this new approach promotes a more conservative cavity design, which relies on the effectiveness of current enamel-dentine adhesives. Adhesive dentistry began in 1955 by Buonocore on the benefits of acid etching. With changing technologies, dental adhesives have evolved from no-etch to total-etch (4th and 5th generation) to self-etch (6th, 7th and 8th generation) systems. Currently, bonding to dental substrates is based on three different strategies: 1) etch-and-rinse, 2) self-etch and 3) resin-modified glass-ionomer approach as possessing the unique properties of self-adherence to the tooth tissue. More recently, a new family of dentin adhesives has been introduced (universal or multi-mode adhesives), which may be used either as etch-and-rinse or as self-etch adhesives %K dental bonding agents %K smear layer %K adhesive systems %K self-etch %K etch-and-rinse %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507161/