%0 Journal Article
%T Ageİ\dependent changes and biomarkers of aging in Caenorhabditis elegans
%A Eun Ji E. Kim
%A Heehwa G. Son
%A Ozlem Altintas
%A Sujeong Kwon
%J Archive of "Aging Cell".
%D 2019
%R 10.1111/acel.12853
%X Caenorhabditis elegans is an exceptionally valuable model for aging research because of many advantages, including its genetic tractability, short lifespan, and clear ageİ\dependent physiological changes. Aged C. elegans display a decline in their anatomical and functional features, including tissue integrity, motility, learning and memory, and immunity. Caenorhabditis elegans also exhibit many ageİ\associated changes in the expression of microRNAs and stressİ\responsive genes and in RNA and protein quality control systems. Many of these ageİ\associated changes provide information on the health of the animals and serve as valuable biomarkers for aging research. Here, we review the ageİ\dependent changes in C. elegans and their utility as aging biomarkers indicative of the physiological status of aging
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413654/