%0 Journal Article
%T Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study
%A Alexis N. Simpkins
%A Amie W. Hsia
%A Devon Kelley
%A John K. Lynch
%A John M. Hallenbeck
%A Kory R. Johnson
%A Lawrence L. Latour
%A Marie Luby
%A Richard Leigh
%A Richard T. Benson
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2019
%R 10.1002/acn3.757
%X We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion¨Cdiffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion¨Cdiffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z©\score £¿2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469246/