%0 Journal Article
%T Cytokine removal in human septic shock: Where are we and where are we going?
%A Eric Hoste
%A Manu L. N. G. Malbrain
%A Olivier Joannes-Boyau
%A Patrick M. Honore
%A Rita Jacobs
%A Zsolt Moln¨¢r
%J Archive of "Annals of Intensive Care".
%D 2019
%R 10.1186/s13613-019-0530-y
%X Cytokine response after sepsis. Normal and abnormal immune response after an (infectious) insult (A). Recovery with regaining of the homeostatic balance occurs when pro-inflammatory (solid red line) and anti-inflammatory (solid blue line) mediators (B) return back to baseline levels. Early death or fulminant septic shock (C) can occur following early increased innate pro-inflammatory response (cytokine storm, dotted red line) or after initial adaptive immunosuppression (dashed blue line). Immunoparalysis (D) can occur following early increased adaptive anti-inflammatory response (immunosuppression, dotted blue line) or after initial pro-inflammatory response (dashed red line). Haemoadsorption with Cytosorb£¿ may attenuate the initial pro- (bold red line) and anti-inflammatory (bold blue line) response resulting in early recovery (E
%K Blood purification
%K Cytokines
%K Sepsis
%K Septic shock
%K Haemoperfusion
%K Cytosorb
%K Sorbents
%K Cartridges
%K Immune modulation
%K DAMPS
%K PAMPS
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517449/