%0 Journal Article
%T Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study
%A Hirotomo Yamanashi
%A Jun Koyamatsu
%A Kairi Kiyoura
%A Kazuhiko Arima
%A Mako Nagayoshi
%A Mami Tamai
%A Shin-Ya Kawashiri
%A Shoichi Fukui
%A Takahiro Maeda
%A Yuji Shimizu
%A Yuko Noguchi
%J Archive of "Aging (Albany NY)".
%D 2019
%R 10.18632/aging.101768
%X Recent studies have revealed an inverse association between height and cardiovascular disease and that endothelial progenitor cells (CD34-positive cells) contribute to vascular maintenance, which is associated with cardiovascular disease. However, evidence of the association between height and CD34-positive positive cells among elderly participants is limited. To assess this association, we conducted a cross-sectional study of 231 elderly Japanese men aged 65¨C69. Since enhanced production of circulating CD34-positive cells in response to endothelial injury might act have a strong confounding effect on the association between height and circulating CD34-positive cells, the median value for the levels of these cells (0.93 cells/¦ÌL) was used to stratify the participants. Multivariable linear regression analysis demonstrated that height was significantly positively associated with circulating CD34-positive cells for those participants with low levels of circulating CD34-positive cells (n=114) but not for those with higher levels (n=117), with a multi-adjusted standardized parameter estimate (¦Â) of 0.27 (p=0.008) for low and 0.11 (0.275) for higher circulating CD34-positive cell levels. The positive association is limited to participants with relatively low circulating CD34-positive cell levels, whose productivity of these cells is not activated. Our findings indicate that height is an indicator of vascular maintenance capability in elderly Japanese men
%K CD34-positive cell
%K consumptive reduction
%K elderly men
%K height
%K vascular maintenance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366994/