%0 Journal Article
%T The role of cholesterol metabolism in cancer
%A Song Li
%A Weihua Zhang
%A Xiao Ding
%J Archive of "American Journal of Cancer Research".
%D 2019
%X Cholesterol plays an important role in cancer development. Both clinical and experimental studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect cancer development. External cholesterol can directly activate the oncogenic Hedgehog pathway, and internal cholesterol can induce mTORC1 signaling. Cholesterol is a key component of lipid rafts, which are the major platforms for signaling regulation in cancer, and chelating membrane cholesterol is an effective anti-cancer strategy that disrupts the functions of lipid rafts. Cholesterol metabolism is often reprogrammed in cancer cells. Targeting cholesterol metabolism as a new therapeutic approach has received increasing attention. Here, we summarize some key molecular mechanisms supporting the use of anti-cholesterol therapy for cancer treatment
%K Cancer
%K cholesterol
%K metabolism
%K oncogenic signaling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405981/