%0 Journal Article
%T C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner
%A Chen Liang
%A Jian-Fu Chen
%A Mei Yang
%A Qiang Shao
%A Qing Chang
%A Wei Zhang
%J Archive of "Acta Neuropathologica Communications".
%D 2019
%R 10.1186/s40478-019-0685-7
%X C9orf72 dose is critical for motor deficits in C9ALS/FTD mouse models. a Western blot analysis of C9orf72 and Atg101 protein levels in 2-month-old mouse cortex. ¦Â-Actin serves as the loading control. b, c Accelerating rotarod test was performed on 4-month-old mice to examine the latency to fall of females (b) and males (c). C9orf72 deficiency decreases the latency to fall of C9-BAC female mice in a dose-dependent manner. d A 4-consecutive-day rotarod assay reveals defective motor learning in C9orf72+/£¿;C9-BAC and C9orf72£¿/£¿;C9-BAC female mice in comparison to WT. e, f Grip strength test was performed to measure front paw strength in 4-month-old females (e) and males (f). All data are presented as mean£¿¡À£¿SEM using numbers (n) of mice as indicated. Statistical analyses were performed with one-way ANOVA with Bonferroni¡¯s post hoc test (*p£¿<£¿0.05, **p£¿<£¿0.01, ***p£¿<£¿0.001, N.s represents no significant difference detected in measurement of 2d, 3d, or 4d in comparison to that of 1d
%K C9orf72
%K Motor deficits
%K C9ALS/FTD
%K Mice
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398253/