%0 Journal Article
%T In Silico Exploration of Aryl Halides Analogues as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and ADMET Screening
%A Abdelouhid Sbai
%A Adib Ghaleb
%A Adnane Aouidate
%A Mohammed Bouachrine
%A Tahar Lakhlifi
%J Archive of "Advanced Pharmaceutical Bulletin".
%D 2019
%R 10.15171/apb.2019.011
%X Purpose: In this review, a set of aryl halides analogs were identified as potent checkpoint kinase 1 (Chk1) inhibitors through a series of computer-aided drug design processes, to develop models with good predictive ability, highlight the important interactions between the ligand and the Chk1 receptor protein and determine properties of the new proposed drugs as Chk1 inhibitors agents
%K 3D-QSAR
%K Molecular-docking
%K In silico ADMET
%K Chk1 inhibitors
%K Aryl halides
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468235/