%0 Journal Article
%T GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology
%A Andrew R. Wood
%A Benjamin Neale
%A Cecilia M. Lindgren
%A Chia-Yen Chen
%A Craig A. Glastonbury
%A Jamie W. Harrison
%A Jenny Censin
%A Jessica Tyrrell
%A Jonas Bovijn
%A Jordan W. Smoller
%A Katherine S. Ruth
%A Leigh Jackson
%A Michael N. Weedon
%A Michael V. Holmes
%A Reedik M£¿gi
%A Robin N. Beaumont
%A Samantha Laber
%A Samuel E. Jones
%A Sara L. Pulit
%A Teresa Ferreira
%A Triin Laisk
%J Archive of "American Journal of Human Genetics".
%D 2019
%R 10.1016/j.ajhg.2018.11.004
%X Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 ¡Á 10£¿14), located between MCHR2 and SIM1. In silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation. Mendelian randomization provides evidence that genetic risk of type 2 diabetes mellitus is a cause of ED (OR 1.11 per 1-log unit higher risk of type 2 diabetes). These findings provide insights into the biological underpinnings and the causes of ED and may help prioritize the development of future therapies for this common disorder
%K erectile dysfunction
%K impotence
%K diabetes
%K SIM1
%K GWAS
%K genome-wide association
%K Mendelian randomization
%K mendelian randomisation
%K UK biobank
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323625/