%0 Journal Article
%T Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level¨Cdependent functional magnetic resonance imaging study in elderly adults
%A Ahmad R. Hariri
%A Brenda L. Plassman
%A Daniel K. Burns
%A James R. Burke
%A Jingtao Wu
%A Kathleen A. Welsh-Bohmer
%A Michael Kukulka
%A Stephen K. Brannan
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2019
%R 10.1016/j.trci.2019.05.004
%X Mitochondrial dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). Accordingly, drugs that positively influence mitochondrial function are being evaluated in delay-of-onset clinical trials with at-risk individuals. Such ongoing clinical research can be advanced by developing a better understanding of how these drugs affect intermediate brain phenotypes associated with both AD risk and pathophysiology
%K Alzheimer's disease
%K Blood oxygen level¨Cdependent functional magnetic resonance imaging
%K Mnemonic hippocampal activity
%K Pioglitazone
%K Thiazolidinediones
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603333/