%0 Journal Article
%T The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease
%A Dan Li
%A Paul S. Aisen
%A Samuel Iddi
%A Wesley K. Thompson
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2019
%R 10.1016/j.trci.2019.04.004
%X Clinical trials on preclinical Alzheimer¡¯s disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression
%K Clinical trial simulations
%K Alzheimer's disease
%K Cox proportional hazards model
%K Longitudinal data
%K Mixed model of repeated measures (MMRM)
%K Statistical power
%K Common close design
%K Bayesian joint mixed-effect model
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656701/