%0 Journal Article
%T IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice
%A Bin He
%A Hai-yan Hu
%A Hong Wang
%A Kao-xiang Sun
%A Tao Tan
%A Ya-ping Li
%J Archive of "Acta Pharmacologica Sinica".
%D 2018
%R 10.1038/aps.2017.109
%X Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PTT applications in treatment of metastatic breast cancer
%K cancer metastasis
%K lymphatic metastasis
%K IR-780
%K polymeric micelles
%K photothermal therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758660/