%0 Journal Article
%T Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system
%A Haiyan Chen
%A Jimin Han
%A Ling Guo
%A Ruiyun Tian
%A Shan Wang
%A Wenpeng Guo
%A Xiaowei Zeng
%A Xusheng Wang
%A Yanjiang Han
%A Yaojiong Wu
%A Yu Jin
%J Archive of "Acta Pharmaceutica Sinica. B".
%D 2019
%R 10.1016/j.apsb.2018.08.006
%X Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey. IR-780 dye, a fluorescent probe used to represent docetaxel (DTX) in NP, delivered via MSC accumulated in the lung. Both in vitro MSC/A549 cell experiments and in vivo MSC/lung cancer experiments validated the intercellular transportation of NP between MSC and cancer cells. In vivo assays showed that the MSC/NP/DTX drug delivery system exerted primary tumor inhibition efficiency similar to that of a NP/DTX drug system. Collectively, the MSC/NP drug delivery system is promising for lung-targeted drug delivery for the treatment of lung cancer and other lung-related diseases
%K Mesenchymal stem cells
%K Nanoparticle
%K Drug delivery
%K KrasG12D
%K Lung cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362298/