%0 Journal Article
%T Septal hypertrophy and cell cycle re-entry in AD
%A Craig S. Atwood
%A Richard Bowen
%A Tracy Butler
%J Archive of "Aging (Albany NY)".
%D 2019
%R 10.18632/aging.101777
%X Using MRI, we recently demonstrated enlargement of basal forebrain septal nuclei in healthy, cognitively-intact subjects destined to develop Alzheimer¡¯s Disease (AD) in an average of approximately three years [1]. Others have shown enlargement/thickening of medial temporal lobe gray matter structures including the hippocampi in subjects with AD pathology but without cognitive impairment [2]. Septal nuclei and hippocampi are structurally and functionally closely connected via the fimbria/fornix and together are critical for memory performance. Enlargement of these structures in association with risk of AD is counterintuitive, as AD is a neurodegenerative disease associated with loss of gray matter volume
%K Alzheimer¡¯s Disease
%K magnetic resonance imaging
%K basal forebrain
%K luteinizing hormone
%K septal nuclei
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366959/