%0 Journal Article
%T VIG-1 is required for maintenance of genome stability in Caenorhabditis elegans
%A Bala Murali Krishna Vasamsetti
%A Yang-Seo Park
%J Archive of "Animal Cells and Systems".
%D 2018
%R 10.1080/19768354.2018.1476410
%X To explore the function of VIG-1 in Caenorhabditis elegans, we analyzed the phenotypes of two vig-1 deletion mutants: vig-1(tm3383) and vig-1(ok2536). Both vig-1 mutants exhibited phenotypes associated with genome instability, such as a high incidence of males (Him) and increased embryonic lethality. These phenotypes became more evident in succeeding generations, implying that the germline of vig-1 accumulates DNA damage over generations. To examine whether vig-1 causes a defect in the DNA damage response, we treated worms with UV or camptothecin, a specific topoisomerase I inhibitor. We observed that the embryonic survival of the vig-1 mutants was reduced compared with that of the wild-type worms. Our results thus suggest that VIG-1 is required for maintaining genome stability in response to endogenous and exogenous genotoxic stresses
%K Caenorhabditis elegans
%K chromosome segregation
%K DNA damage response
%K genome stability
%K VIG-1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138327/