%0 Journal Article
%T Brain histopathological study and prognosis in MOG antibody©\associated demyelinating pseudotumor
%A Alexander Y. Lau
%A Allan G. Kermode
%A Chen Chen
%A Huiming Xu
%A Jian Zhou
%A Shisi Wang
%A Wanming Hu
%A Xinhua Yu
%A Yangmei Ou
%A Yaqing Shu
%A Youming Long
%A Zhengqi Lu
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2019
%R 10.1002/acn3.712
%X Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody©\associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody©\associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement©\mediated demyelination, which was in accord with multiple sclerosis©\like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein©\encephalomyelitis spectrum, which favorably responds to immunotherapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389737/