%0 Journal Article
%T Novel C-17 spirost protostane-type triterpenoids from Alisma£¿plantago-aquatica£¿with anti-inflammatory activity in£¿Caco-2£¿cells
%A Bang Yeon Hwang
%A Chen Liu
%A Jianqing Zhang
%A Jinjun Hou
%A Min Lei
%A Qinghao Jin
%A Shuai Yao
%A Wanying Wu
%A Xia Wang
%A Yong Huang
%J Archive of "Acta Pharmaceutica Sinica. B".
%D 2019
%R 10.1016/j.apsb.2019.04.002
%X Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds (1¨C9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A£¿F (1¨C6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H (8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I (9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4£¿6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76¨C38.20 ¦Ìmol/L
%K Alisma plantago-aquatica Linn.
%K Protostane-type triterpenoids
%K Caco-2 cells
%K LPS-induced NO production
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664094/