%0 Journal Article
%T DIFFERENTIATED THYROID CANCER IN PEDIATRIC POPULATION (¡Ü18 YEARS): POSTOPERATIVE TREATMENT WITH RADIOACTIVE IODINE (I-131)
%A Ante Bolan£¿a
%A Davor Kust
%A Maja Franceschi
%A Marin Prpi£¿
%A Marko Lucijani£¿
%A Nina Dabeli£¿
%A Tea Varja£¿i£¿
%A Tomislav Juki£¿
%A Zvonko Kusi£¿
%J Archive of "Acta Clinica Croatica".
%D 2019
%R 10.20471/acc.2019.58.01.16
%X The aim is to present data on the treatment and follow-up in a cohort of patients with pediatric thyroid cancer who underwent total thyroidectomy and received postoperative radioactive iodine (I-131) therapy. The study was conducted in a tertiary high-volume thyroid center, in pediatric patients with differentiated thyroid cancer who were consecutively treated during the 1965-2015 period. A total of 45 patients aged ¡Ü18 years having undergone total thyroidectomy with or without selective neck dissection were included in the study. Decision on postoperative I-131 ablation was based on tumor characteristics, postoperative thyroglobulin level, preablative whole body scintigraphy, and/or neck ultrasound. Median age at diagnosis was 15 years. The presence of cervical lymph node metastases was significantly associated with papillary thyroid cancer, larger tumor size, involvement of two thyroid lobes, and multifocal disease. The presence of distant metastases was significantly associated with larger tumor size. None of the patients died during follow-up period, and the 5-year and 10-year overall survival rates were 100%. The 5-year and 10-year progression-free survival (PFS) rates were 87% and 73%, respectively. Male gender (p=0.046), age ¡Ü15 years (p=0.029) and tumor size >15 mm (p=0.042) were significantly associated with inferior PFS. A significant positive trend of increase in the number of newly diagnosed patients was observed over time (p=0.011). Clinical management of pediatric thyroid cancer is challenging, especially in the light of increasing incidence in this population. Male patients younger than 15 years and with tumors of more than 15 mm in size require additional caution due to lower PFS observed
%K Iodine
%K Thyroid cancer
%K papillary
%K Adenocarcinoma
%K follicular
%K Survival rate
%K Child
%K Follow-up studies
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629190/