%0 Journal Article
%T Preparation and Characterization of a Dry Powder Inhaler Composed of PLGA Large Porous Particles Encapsulating Gentamicin Sulfate
%A Bibi Sedigheh Fazly Bazzaz
%A Faezeh Mashhoori
%A Farideh Shiehzadeh
%A Majid-Laal Dehghani
%A Mohsen Imenshahidi
%A Mohsen Tafaghodi
%J Archive of "Advanced Pharmaceutical Bulletin".
%D 2019
%R 10.15171/apb.2019.029
%X Purpose: Direct delivery of aminoglycosides to the lungs was under extensive evaluations during the last decades. Because of large particle size, low density and porous structure, large porous particles (LPPs) are versatile carriers for this purpose. In this study, poly (lactic-co-glycolic acid) (PLGA) LPPs encapsulating gentamicin sulfate were prepared and in vitro characteristics of their freeze-dried powder as a dry powder inhaler (DPI) were evaluated
%K Aminoglycosides
%K Drug delivery systems
%K Dry powder inhalers
%K Gentamicin sulfate
%K Large porous particles
%K Lung
%K PLGA
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664120/