%0 Journal Article %T Zein-CMC-PEG Multiple Nanocolloidal Systems as a Novel Approach for Nutra-Pharmaceutical Applications %A Bingyang Shi %A Hamed Hamishehkar %A Mahnaz Tabibiazar %J Archive of "Advanced Pharmaceutical Bulletin". %D 2019 %R 10.15171/apb.2019.030 %X Purpose: Hydrophobic nutraceuticals are suffering from water solubility and physicochemical stabilities once administered to the body or food matrixes. The present study depicts the successful formulation of a zein-carboxymethyl cellulose (CMC) complex to stabilize a water in oil (W/O) emulsion to protect them from environmental and gastrointestinal conditions. The formulated water in oil in water (W/O/W) system was used for nanoencapsulating of hydrophobic nutraceutical, rutin, via protein-polysaccharide complexes %K Carboxymethyl cellulose %K Nanoencapsulation %K Protein-polysaccharide complex %K Rutin %K Zein nanoparticles %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664118/