%0 Journal Article
%T Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei
%A Ho-Chang Lee
%A Jang Jin Kim
%A Sang-Jeon Lee
%A Sung Su Park
%A Taek-Gu Lee
%J Archive of "Annals of Coloproctology".
%D 2018
%R 10.3393/ac.2018.02.27
%X Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of colonoscopic biopsy performed at a local clinic was a poorly differentiated carcinoma. An abdominopelvic computed scan revealed irregularly enhanced wall thickening at the sigmoid colon with regional fat stranding and lymphnode enlargement. He underwent a laparoscopic high anterior resection with selective peritonectomy for peritoneal carcinomatosis, intraoperative peritoneal irrigation chemotherapy, and early postoperative intraperitoneal chemotherapy for 5 days. The tumor had a high proliferation rate (mitotic count > 50/10 HPFs and 90% of the Ki-67 index) and lymph-node metastases had occurred. On immunohistochemistry, the tumor cells expressed CD56 and synaptophysin. Large-cell NEC was confirmed. Systemic chemotherapy with cisplatin/etoposide was done. The patient is still alive after 3 years with no evidence of recurrence
%K Large-cell neuroendocrine carcinoma
%K Colon
%K Peritoneal carcinomatosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140363/