%0 Journal Article
%T Can levodopa prevent cognitive decline in patients with Parkinson¡¯s disease?
%A Hiroshi Kataoka
%A Masahiro Ikeda
%A Satoshi Ueno
%J Archive of "American Journal of Neurodegenerative Disease".
%D 2017
%X Cognitive impairment in Parkinson¡¯s disease (PD) will become more important since the number of elderly patients with PD is increasing. We prospectively studied non-demented patients with PD over the course of 3 years to identify factors associated with PD that contribute to a decline in cognitive function. From among 100 consecutive patients, we registered 79 patients with PD. A total of 55 patients completed the study during 3 years and were divided to two groups: patients with a decline in cognitive function and those without a decline in cognitive function after 3 years. Seventeen independent variables were evaluated with the use of logistic regression models. The increase in the daily levodopa dose was related to a decline in cognitive function on univariate logistic regression analysis (OR = 0.279, p = 0.024, 95% CI = 0.092-0.848). Other variables were not related to a decline in cognitive function. The increase in the daily dose of levodopa was greater in patients without a decline in cognitive function than those with a decline in cognitive function; on the other hand, the cognitive function unchanged. Our results suggest that the treatment with levodopa might prevent a decline in cognitive function in PD
%K Parkinson
%K levodopa
%K cognition
%K dementia
%K dopamine
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498848/