%0 Journal Article
%T A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration
%A Hiroko Yamamoto-Hanasaki
%A Hiromi Rakugi
%A Hiroshi Akasaka
%A Hiroshi Kusunoki
%A Kazunori Ikebe
%A Ken Sugimoto
%A Koichi Yamamoto
%A Mitsuru Ohishi
%A Miyuki Takeya-Onishi
%A Norihisa Ito
%A Ryosuke Oguro
%A Serina Yokoyama
%A Tatsuo Kawai
%A Yasushi Takeya
%A Yasuyuki Gondo
%J Archive of "Aging (Albany NY)".
%D 2019
%R 10.18632/aging.101728
%X Klotho protects against development of multiple age-related disorders, including cardiovascular diseases. We assessed whether a human klotho single nucleotide polymorphism (SNP) rs650439 is associated with the onset of stroke in hypertensive patients and plasma klotho concentration in the general population. Five hundred and twenty-three patients with hypertension were analyzed for both the presence of rs650439 and onset of stroke. We found that hypertensive patients with the TT genotype of rs650439 (n=52) had a higher incidence of stroke than those with AT (n=257) and AA (n=214) genotypes. Multivariate analysis indicated that the TT genotype was the only risk factor associated with increased incidence of stroke. Plasma klotho concentrations were measured in a general population (age=70¡À1 years) to assess the association between rs650439 and plasma klotho concentration. A significant trend was observed in the elderly population where plasma klotho concentration decreased as the T alleles in rs650439 increased. Subjects with a TT genotype had lower plasma klotho concentrations than those with AT+AA genotypes. In conclusion, TT genotype of klotho SNP (rs650439) is correlated with an increased incidence of stroke in hypertensive patients, and the mechanism underlying this correlation might involve the effect of rs650439 T allele on plasma klotho concentrations
%K klotho
%K stroke
%K atherosclerosis
%K SNP
%K plasma klotho concentration
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339800/