%0 Journal Article
%T OXYTOCIN REDUCES SEIZURE BURDEN AND HIPPOCAMPAL INJURY IN A RAT MODEL OF PERINATAL ASPHYXIA
%A A. Totan
%A A.M. Panaitescu
%A A.M. Zagrean
%A A.S. Ilie
%A B. Pavel
%A G. Peltecu
%A L. Zagrean
%A M. Ceanga
%A S. Isac
%J Archive of "Acta Endocrinologica (Bucharest)".
%D 2018
%R 10.4183/aeb.2018.315
%X Foetal asphyxia, a frequent birth complication, detrimentally impacts the immature brain, resulting in neuronal damage, uncontrolled seizure activity and long-term neurological deficits. Oxytocin, a neurohormone mediating important materno-foetal interactions and parturition, has been previously suggested to modulate the immature brain¡¯s excitability, playing a neuroprotective role. Our aim was to investigate the effects of exogenous oxytocin administration on seizure burden and acute brain injury in a perinatal model of asphyxia in rats
%K perinatal asphyxia
%K oxytocin
%K hippocampus
%K S100B
%K loss of righting reflex
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525763/