%0 Journal Article
%T Computational analysis of ligand¨Creceptor interactions in wild-type and mutant erythropoietin complexes
%A Nicholas J Pekas
%J Archive of "Advances and Applications in Bioinformatics and Chemistry : AABC".
%D 2018
%R 10.2147/AABC.S177206
%X Erythropoietin (EPO), a pleiotropic cytokine, binds to its receptor (EPOR) in bone marrow, activating a signaling cascade that results in red blood cell proliferation. A recently discovered naturally occurring EPO mutation (R150Q) at active site 1 (AS1) of the protein was shown to attenuate its canonical downstream signaling, eliminating its hematopoietic effects and causing a fatal anemia. The purpose of this work was to analyze the EPO¨CEPOR complex computationally to provide a structural explanation for this signaling change
%K molecular dynamics
%K signaling cascade
%K binding affinity
%K hematopoiesis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197206/