%0 Journal Article
%T Estrogen Receptor ¦Á- and ¦Â-Interacting Proteins Contain Consensus Secondary Structures: An Insilico Study
%A Harini Krishnan
%A Mahendra Kumar Thakur
%J Archive of "Annals of Neurosciences".
%D 2018
%R 10.1159/000481809
%X Estrogen receptor (ER)¦Á and ER¦Â are ligand-activated transcription factors that regulate gene expression by binding to estrogen-responsive elements and interacting with several coregulators through protein-protein interactions. Usually, these coregulators bind to the various conserved and functional domains of the receptor through a consensus LXXLL sequence, although variations can be found. The interaction of receptor domains and the consensus motif can be a possible target for nuclear receptor (NR) pharmacology, since modifications in these are responsible for possible pathogenesis of various diseases
%K Estrogen receptor ¦Á
%K Estrogen receptor ¦Â
%K Estrogen receptor coregulators
%K Secondary structure
%K Homology
%K Insilico study
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981639/