%0 Journal Article
%T Allergic reactions to cowdĄŻs milk proteins in medications in childhood
%A Andreozzi Laura
%A Caffarelli Carlo
%A Mastrorilli Carla
%A Ricci Giampaolo
%A Santoro Angelica
%J Archive of "Acta Bio Medica : Atenei Parmensis".
%D 2019
%R 10.23750/abm.v90i3-S.8169
%X Introduction: CowĄŻs milk is a frequent trigger of allergic reactions in childhood. CowĄŻs milk proteins can be present in pharmaceutical excipients. Methods: We have analyzed paediatric literature on allergic reactions to cowĄŻs milk proteins in medication, focusing on the different routes of administration (inhaled, parental and oral). Results: Dry-powder inhalers may contain lactose as excipient. Lactose can be rarely contaminated with milk proteins and it may induce allergic reactions in patients with cowĄŻs milk allergy. Case reports have described immediate hypersensitivity reactions to methylprednisolone sodium succinate 40 mg injection, a formulation that contains lactose as excipient. Some cases of anaphylaxis after receiving diphteria-tetanus-pertussis vaccine injection in children allergic to milk have been reported. CowĄŻs milk proteins can be detected also in oral polio vaccine, certain probiotics and lactulose syrup. Conclusions: We suggest caution in administration of pharmaceuticals containing milk allergens in children allergic to milk. (www.actabiomedica.it
%K cowĄŻs milk allergy
%K drug allergy
%K probiotics
%K vaccine
%K skin prick test
%K anaphylaxis
%K patch test
%K challenge test
%K lactose
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502173/