%0 Journal Article
%T American tegumentary leishmaniasis: severe side effects of
pentavalent antimonial in a patient with chronic renal failure
%A Maira Renata Merlotto
%A Mariangela Esther Alencar Marques
%A Paulo M¨šller Ramos
%A S¨Ēlvio Alencar Marques
%J Archive of "Anais Brasileiros de Dermatologia".
%D 2019
%R 10.1590/abd1806-4841.20198388
%X Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis
%K Amphotericin B
%K Kidney failure
%K chronic
%K Leishmaniasis
%K Leishmaniasis
%K cutaneous
%K Meglumine
%K Pancreatitis
%K Renal insufficiency
%K chronic
%K Skin ulcer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668951/