%0 Journal Article
%T TGF-BETA IN THE NATURAL HISTORY OF PROSTATE CANCER
%A Hrvoje Nikles
%A Jamal Ahel
%A Narcis Hudorovi£¿
%A Vi£¿nja Vi£¿i£¿-Hudorovi£¿
%J Archive of "Acta Clinica Croatica".
%D 2019
%R 10.20471/acc.2019.58.01.17
%X All transforming growth factors beta (TGF£¿) are cytokines that regulate several cellular functions such as cell growth, differentiation and motility. They may also have a role in immunosuppression. Their role is important for normal prostate development. TGF£¿ is active in the regulation of balance between epithelial cell proliferation and apoptosis through stromal epithelia via the androgen receptor action. TGF£¿ protects and maintains prostate stem cells, an important population necessary for prostate tissue regeneration. However, TGF£¿ is shown to have a contrasting role in prostate tumor genesis. In the early stages of tumor development, TGF£¿ acts as a tumor suppressor, whereas in the later stages, TGF£¿ becomes a tumor promoter by inducing proliferation, invasion and metastasis. In this review, we outline complex interactions that TGF£¿-mediated signaling has on prostate tumor genesis, focusing on the role of these interactions during the course of prostate cancer and, in particular, during disease progression
%K Transforming growth factor beta
%K Prostatic neoplasms
%K Disease progression
%K Receptors
%K androgen
%K Stem cells
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629207/