%0 Journal Article
%T Reg3¦Â from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis
%A Han Jiang
%A Han Wang
%A Hongxiang Lu
%A Huaxi Xu
%A Rong Chen
%A Shanshan Zhou
%A Zhaoliang Su
%J Archive of "American Journal of Clinical and Experimental Immunology".
%D 2018
%X Macrophages play critical roles in inflammatory initiation, development, resolution and cardiac regeneration of myocarditis. However, Reg3¦Â, as a member of regenerating family of proteins, contributes to dedifferentiation of injury cardiomyocytes as well as cardiac function remodeling. It remains unclear whether Reg3¦Â was associated with macrophages reprogramming during autoimmune myocarditis. Our results showed that Reg3¦Â could effectively recruit macrophages, promoted their proliferation and phagocytosis, and facilitated their polarized into M2 macrophages. Macrophage, especially M1 phenotype contributed to Reg3¦Â production by cardiomyocytes. Our data also indicated that Reg3¦Â was involved in self-protection mechanism following cardiac injury or stress. This suggests that Reg3¦Â might be a critically protective factor of myocardium
%K Cardiomyocytes
%K dedifferentiation
%K macrophage reprogramming
%K M2 phenotype
%K phagocytosis
%K Reg3¦Â
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944813/