%0 Journal Article
%T Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications
%A Liz Simon
%A Patricia E. Molina
%A Sarah E. Jolley
%J Archive of "Alcohol Research : Current Reviews".
%D 2017
%X Skeletal muscle dysfunction (i.e., myopathy) is common in patients with alcohol use disorder. However, few clinical studies have elucidated the significance, mechanisms, and therapeutic options of alcohol-related myopathy. Preclinical studies indicate that alcohol adversely affects both anabolic and catabolic pathways of muscle-mass maintenance and that an increased proinflammatory and oxidative milieu in the skeletal muscle is the primary contributing factor leading to alcohol-related skeletal muscle dysfunction. Decreased regenerative capacity of muscle progenitor cells is emerging as an additional mechanism that contributes to alcohol-induced loss in muscle mass and impairment in muscle growth. This review details the epidemiology of alcoholic myopathy, potential contributing pathophysiologic mechanisms, and emerging literature on novel therapeutic options
%K Alcohol consumption
%K alcohol use disorder
%K alcohol effects and consequences
%K alcoholic myopathy
%K skeletal muscle
%K skeletal muscle dysfunction
%K myopathy
%K muscle
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513686/