%0 Journal Article
%T GESTATIONAL DIABETES MELLITUS AND THE DEVELOPMENT OF CLEFT LIP / PALATE IN NEWBORNS
%A A. Kozma
%A C.L. Bohaltea
%A H. Lazarescu
%A R. Ursu
%A S. Carniciu
%A V. Radoi
%J Archive of "Acta Endocrinologica (Bucharest)".
%D 2019
%R 10.4183/aeb.2019.118
%X Several studies observed metabolic disorders in pregnancy as risk factors for birth defects, including orofacial clefts. Diabetes is associated with approx. 10% of the pregnancies, but in Romania, less than 5%. An obese and diabetic woman has 3 times more risk for an offspring with a craniofacial defect than healthy women suggesting that diabetes mellitus contributes to their pathogenesis with complex mechanisms
%K orofacial cleft
%K gestational diabetes mellitus
%K GDM
%K birth defect
%K diabetes
%K teratogenesis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535315/