%0 Journal Article
%T Cardiac diseases as a predictor warning of hereditary muscle diseases. The case of laminopathies
%A ALBERTO PALLADINO
%A ANDREA ANTONIO PAPA
%A ANNALAURA TORELLA
%A ANTONIO NOVELLI
%A CHIARA ORSINI
%A LUIGIA PASSAMANO
%A LUISA POLITANO
%A MANUELA ERGOLI
%A PAOLA DĄŻAMBROSIO
%A ROBERTA PETILLO
%A VINCENZO NIGRO
%J Archive of "Acta Myologica".
%D 2019
%X Mutations in the LMNA gene are associated with a wide spectrum of disease phenotypes, ranging from neuromuscular, cardiac and metabolic disorders to premature aging syndromes. Skeletal muscle involvement may present with different phenotypes: limb-girdle muscular dystrophy type 1B or LMNA-related dystrophy; autosomal dominant Emery-Dreifuss muscular dystrophy; and a congenital form of muscular dystrophy, frequently associated with early onset of arrhythmias. Heart involvement may occur as part of the muscle involvement or independently, regardless of the presence of the myopathy. Notably conduction defects and dilated cardiomyopathy may exist without a muscle disease
%K laminopathies
%K risk stratification
%K genetic counselling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598412/