%0 Journal Article
%T Immunohistochemical Localization of RNase 7 in Normal and Inflamed Oral Epithelia and Salivary Glands
%A Aya Onishi
%A Bhoj Raj Adhikari
%A Daichi Hiraki
%A Durga Paudel
%A Itsuo Chiba
%A Jun Sato
%A Koki Yoshida
%A Michiko Nishimura
%A Osamu Uehara
%A Puja Neopane
%A Tetsuro Morikawa
%A Yoshihiro Abiko
%J Archive of "Acta Histochemica et Cytochemica".
%D 2019
%R 10.1267/ahc.18027
%X RNase 7 is a skin-derived antimicrobial peptide expressed in various epithelial tissues. It is upregulated by stimulation with microbes and pro-inflammatory cytokines. Herein, we examined the expression levels of RNase 7 in tissues from normal and inflamed oral epithelia and salivary glands via immunohistochemistry. RNase 7 was expressed mainly in the surface layers of the parakeratinized and orthokeratinized oral epithelium. In addition, it was strongly and weakly expressed in oral lichen planus and radicular cysts, respectively. RNase 7 was constitutively expressed in salivary glands, particularly in the serous and duct cells. In the case of SjogrenĄ¯s syndrome, RNase 7 was strongly expressed in serous, ductal, and mucous cells in areas with lymphocytic infiltration. The localization patterns of RNase 7 were similar to those of other epithelial antimicrobial peptides, including beta-defensins. Thus, epithelial antimicrobial peptides may act against microbial infections in a coordinated manner in oral epithelia and salivary glands
%K RNase 7
%K normal oral epithelium
%K oral lichen planus
%K salivary gland
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643094/