%0 Journal Article
%T Estrogen Accelerates Cell Proliferation through Estrogen Receptor ¦Á during Rat Liver Regeneration after Partial Hepatectomy
%A Baatarsuren Batmunkh
%A Mohmand Noor Ali
%A Naparee Srisowanna
%A Narantsog Choijookhuu
%A Phyu Synn Oo
%A Uugantsetseg Byambatsogt
%A Yoshitaka Hishikawa
%A Yuya Yamaguchi
%J Archive of "Acta Histochemica et Cytochemica".
%D 2017
%R 10.1267/ahc.17003
%X Although estrogen is implicated in the regulation of cell growth and differentiation in many organs, the exact mechanism for liver regeneration is not completely understood. We investigated the effect of estrogen on liver regeneration in male and female Wistar rats after 70% partial hepatectomy (PHx) and performed immunohistochemistry, western blotting and Southwestern histochemistry. 17¦Â-estradiol (E2) and ICI 182,780 were injected into male rats on the day before PHx. The proliferating cell nuclear antigen (PCNA) labeling index reached a maximum at 48 hr after PHx in males, and at 36 hr in females and E2-treated male rats. Estrogen receptor ¦Á (ER¦Á) was expressed in zones 1 and 2 in male rats, but was found in all zones in female rats. Interestingly, ER¦Á was not detected at 6¨C12 hr after PHx but was found at 24¨C168 hr in male rats. However, ER¦Á expression was found at all sampling time-points in female and E2-treated male rats. The activity of estrogen responsive element binding proteins was detected from 12 hr after PHx in male rats but was found from 6 hr in female and E2-treated male rats. ER¦Á was co-expressed with PCNA during liver regeneration. These results indicate that estrogen may play an important role in liver regeneration through ER¦Á
%K estrogen
%K estrogen receptor ¦Á
%K liver regeneration
%K partial hepatectomy
%K cell proliferation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374102/