%0 Journal Article
%T ACTN3 gene variants as potential phenotype and performance biomarkers in Brazilian sport horses training for eventing in a tropical climate
%A Aline dos Santos Moreira
%A Ana Maria Reis Ferreira
%A Felipe Gomes Ferreira Padilha
%A Fernando Queiroz de Almeida
%A K那nia Balbi El-Jaick
%A Liane de Castro
%J Archive of "Canadian Journal of Veterinary Research".
%D 2018
%X The aim of this study was to look for mutations in the equine ACTN3 gene and to identify sequence variants that might be associated with the phenotype and performance of Brazilian sport horses training for events in a tropical climate. Among 17 such horses direct DNA sequencing and mutation analysis of the exon 15 and the intron每exon boundaries of ACTN3 revealed 2 new sequence variants in the ACTN3 intron 14每15, designated c.1681每86G > A and c.1681每129delA. Wild-type/deletion heterozygotes (A/del) had a lower mean subcutaneous fat layer in the region of the gluteus medius, as measured by ultrasonography, than the del/del homozygotes; the correlation was significant (P = 0.017). This single base-pair deletion in ACTN3 intron 14每15 may have resulted in metabolic changes that led to increased deposition of body fat in the homozygous state. However, neither sequence variant was correlated with the time to fatigue in a test on a high-speed treadmill with an incremental-speed protocol
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040019/