%0 Journal Article
%T A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
%A Jae-Rim Heo
%A Kyung-A Hwang
%A Kyung-Chul Choi
%A Seung U. Kim
%J Archive of "Cancer Research and Treatment : Official Journal of Korean Cancer Association".
%D 2019
%R 10.4143/crt.2018.364
%X In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into two types: one expressed only the cytosine deaminase (CD) gene (HB1.F3. CD) and the other expressed both CD and human interferon-¦Â (IFN-¦Â) genes (HB1.F3.CD. IFN-¦Â)
%K Melanoma
%K Human neural stem cells
%K Flucytosine
%K Cytosine deaminase
%K Human interferon-¦Â
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473263/