%0 Journal Article
%T 14©\3©\3¦Æ promotes gliomas cells invasion by regulating Snail through the PI3K/AKT signaling
%A Hao Xu
%A Junjun Li
%A Nanxiang Xiong
%A Qiangping Wang
%A Sihua Wang
%J Archive of "Cancer Medicine".
%D 2019
%R 10.1002/cam4.1950
%X 14©\3©\3¦Æ has been reported to function as critical regulators of diverse cellular responses. However, the role of 14©\3©\3¦Æ in gliomas progression remains largely unknown. The expression level of 14©\3©\3¦Æ and Snail was detected by Western blot analysis and quantitative polymerase chain reaction in different grades of human gliomas. The effect of 14©\3©\3¦Æ on gliomas progression was measured using cell migration and invasion assay, the colony formation experiment, and CCK©\8 assay. The effect of 14©\3©\3¦Æ on PI3K/AKT/Snail signaling protein expression levels was tested by Western blotting. Firstly, 14©\3©\3¦Æ was often up©\regulated in high©\grade gliomas relative to low©\grade gliomas, and this overexpression was significantly related to tumor size, Karnofsky Performance Scale score and weaker disease©\free survival. Secondly, the overexpression of 14©\3©\3¦Æ promoted gliomas cells proliferation, migration, and invasion. Conversely, the knockdown of 14©\3©\3¦Æ suppressed gliomas cells proliferation, migration, and invasion. Furthermore, subsequent mechanistic studies showed that 14©\3©\3¦Æ could activate PI3K/AKT /Snail signaling pathway to facilitate gliomas cells proliferation, migration, and invasion. This study shows that the overexpression of 14©\3©\3¦Æ can promote remarkably gliomas cells proliferation, migration, and invasion by regulating the Snail protein expression through activating PI3K/AKT signaling, and it may serve as a potential prognostic marker and therapeutic target for gliomas
%K 14©\3©\3¦Æ
%K gliomas
%K invasion
%K PI3K/AKT
%K Snail
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382716/