%0 Journal Article
%T Overexpression of chloride channel-3 (ClC-3) is associated with human cervical carcinoma development and prognosis
%A Gang Wang
%A Hai-yan Shi
%A Hui Zhou
%A Li-jiang Xu
%A Xi-ming Shen
%A Xiao-lu Zhang
%A Yang-ping Chen
%A Yi Luan
%A Yong Xie
%A Yu-tao Guan
%A Yu-yuan Zhu
%A Zhong-qiu Lin
%J Archive of "Cancer Cell International".
%D 2019
%R 10.1186/s12935-018-0721-x
%X Increased expression levels of the ClC-3 mRNA and protein in paracancerous and carcinoma tissues. A ClC-3 mRNA expression levels were detected by quantitative real time RT-PCR in the control, non-cervical cancer, cervical samples (normal), the corresponding paracancerous normal tissues (PN) and the matched cancer samples (SCC) from 165 patients with cervical cancer. B Densitometric analysis of the ClC-3 protein expression levels in normal, low-squamous intraepithelial lesions (LSIL), high-squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) tissues by immunohistochemistry. C¨CF Images of representative tissues showing the ClC-3 immunohistochemical staining. The main and inserted images were taken by a£¿¡Á£¿40 objective lens. Scale bars, 50 ¦Ìm. G The representative western blot analysis of the ClC3 and ¦Â-actin proteins from normal, PN and SCC tissues. H Densitometric analysis of ClC3 protein levels in different tissues as detected by western blotting. The data in A, B and E are shown as the mean£¿¡À£¿SD. *p£¿<£¿0.05, **p£¿<£¿0.0
%K Chloride channel-3 (ClC-3)
%K Cervical carcinoma
%K Development
%K Prognosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325671/