%0 Journal Article
%T Urinary Hepcidin-25 Is Elevated in Patients That Avoid Acute Kidney Injury Following Cardiac Surgery
%A Ang Gao
%A Brett Hiebert
%A Claudio Rigatto
%A Julie Ho
%A Michael Zappitelli
%A Nora Choi
%A Rakesh C. Arora
%A Simon Christie
%J Archive of "Canadian Journal of Kidney Health and Disease".
%D 2018
%R 10.1177/2054358117744224
%X Acute kidney injury (AKI) following cardiac surgery leads to increased morbidity and mortality. Characterization and validation of early biomarkers of AKI may ultimately facilitate early therapeutic intervention. We have previously identified that elevated urinary hepcidin-25 is inversely and independently associated with the development of AKI in adult cardiac surgery patients. Hepcidin-25 is an antimicrobial peptide that sequesters iron intracellularly, and its elevation following human ischemia reperfusion injury may represent a renoprotective response to minimize renal injury
%K AKI
%K biomarkers
%K cardiac surgery
%K iron
%K ischemia reperfusion injury
%K renoprotection
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788097/