%0 Journal Article
%T Animal models for studying tumor microenvironment (TME) and resistance to lymphocytic infiltration
%A Guy Perkins
%A Ryuji Yamaguchi
%J Archive of "Cancer Biology & Therapy".
%D 2018
%R 10.1080/15384047.2018.1470722
%X In cancer immunotherapy, cytotoxic T or NK cells need to engage cancer cells to initiate the killing. However, in clinical studies and in mouse models, some solid tumors are found with no lymphocytes. It is likely that these tumors will be resistant to all sorts of immunotherapies. Thus, restoring lymphocytic infiltration will be vital to the success of immunotherapies on solid tumors. In order to understand the complex interaction between cancer cells and stromal cells, we propose to establish animal models for studying the tumor microenvironment and to develop and test therapies to restore lymphocytic infiltration of tumors Without lymphocytes infiltrating tumors, all immunotherapies on solid tumors become ineffective
%K CAR T
%K cancer biology
%K chemokine
%K immunotherapy
%K interferon gamma
%K Jak kinases
%K keratin
%K melanoma
%K tumor infiltrating lymphocytes
%K tumor immunology
%K tumor microenvironment
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154837/