%0 Journal Article
%T Effects of a single intravenous bolus injection of alfaxalone on canine splenic volume as determined by computed tomography
%A Clifford R. Berry
%A Fernando L. Garcia-Pereira
%A Gary W. Ellison
%A Michelle M.M. Hasiuk
%J Archive of "Canadian Journal of Veterinary Research".
%D 2018
%X The purpose of this study was to evaluate the effects of a single intravenous dose of alfaxalone on canine splenic volume. In 6 adult beagle dogs the splenic volume [mean ¡À standard error (SE)] was determined by computed tomography to be 0.17 ¡À 0.02 L before alfaxalone administration and 0.24 ¡À 0.02 L (P = 0.0091) and 0.23 ¡À 0.02 L (P = 0.0268) 15 and 30 min, respectively, after alfaxalone administration. Hematocrits (mean ¡À SE) obtained at the same times were, respectively, 46.3% ¡À 1.3%, 40.6% ¡À 1.3% (P = 0.0015), and 41.7% ¡À 1.3% (P = 0.0057). In conclusion, alfaxalone caused relaxation of the canine splenic capsule and an increase in the splenic volume, along with a decrease in the hematocrit in these dogs
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040021/